The second day of the 2022 annual BMUC meeting kicked off with a session addressing three hot topics in the field of kidney cancer. In a first lecture, Prof. Dr. Toni Choueiri (Dana Farber Cancer Institute, Boston, MA, USA) discussed the management of patients with non-clear cell renal cell carcinoma (RCC). Subsequently, Dr. Marco Gizzi (GHdC, Charleroi) turned the attention to the adjuvant treatment of patients with RCC after which he gave an overview of new molecules for patients with metastatic RCC. Dr. Stephanie Kroeze (Universitätsspital Zürich, Zürich, Switzerland) closed the RCC session with a presentation on how to combine radiotherapy with systemic therapy in this setting.