Journal issues > Issue Special, June 2024 > Gut microbiota as a novel source of biomarkers for immunotherapy in NSCLC

Gut microbiota as a novel source of biomarkers for immunotherapy in NSCLC

By: J. Blokken PhD, PharmD, T. Feys MBA, MSc

There is growing interest for biomarkers that allow a better selection of non-small cell lung cancer (NSCLC) patients that are likely to benefit from immunotherapy. To date, several biomarkers are under investigation, including the PD1/PL-L1 axis, the tumour mutational burden, and the gut microbiota. The gut microbiota seems interesting due to its role in cancer, cancer treatment and treatment-related toxicities. Below we briefly summarize the conditions that might influence the composition of the gut microbiota and the subsequent effect on a response to immunotherapy, immune-related adverse events, and their management in NSCLC.¹

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