BJMO - volume 11, issue 1, february 2017
C. Quaghebeur MD, N. Whenham MD, J.P. Machiels MD, PhD, J-P. Haxhe MD, A-P. Schillings MD, E. Laterre MD, X. Catteau MD, R. Poncin MD, L. Duck MD
Breast phyllodes tumours account for less than 0.5% of breast tumours, their diagnosis is therefore often made after pathological exam. They are fibroepithelial lesions of the breast, and are classified as benign, borderline or malignant. For malignant phyllodes tumours, aggressive behaviour with risk of local and distant recurrence may be seen. Therefore, at least one centimetre free-margins, or mastectomy, should be preferred for local malignant tumours. No prospective randomised data exist to elucidate the role of adjuvant chemotherapy, but radiotherapy should probably be offered after breast conservative surgery for borderline and malignant tumours. For metastatic disease, there is no standard chemotherapy regimen. Doxorubicin is the main recommended drug, based on scarce data. Palliative surgery or radiotherapy may also be offered. We present here a patient with lung metastatic disease who partially responded to a platin-etoposide regimen after doxorubicin failure, and make a short review of the literature.
(BELG J MED ONCOL 2017;11(1):26–28)
Read moreBJMO - volume 10, issue 7, november 2016
K. Oualla MD, M. Aoun MD, M. Lemort MD, A. Harrouk MD, S. Latifyan MD, A. Awada MD, PhD, A. Georgala MD
Progressive multifocal leukoencephalopathy is a rare demyelinating condition caused by reactivated JC polyomavirus. This disease occurs mainly in the context of immunodeficiency, usually from human immunodeficiency virus.We report a case of 67 years old patient, treated for metastatic nasopharyngeal epidermoid carcinoma with three lines of chemotherapy, admitted for deterioration of performance status and neurological symptoms represented by agitation, cognitive decline complicated by loss of consciousness, after receiving three cycles of carboplatin-docetaxel. Cerebral imaging had strongly suspected brain metastases given to the context of metastatic neoplasm in progression but cerebrospinal fluid was positive for JC-BK Polyomavirus. Unfortunately, evolution was marked by rapid clinical deterioration leading to death. We report this case in order to underline the rarity of this disease, clinico-radiological features, especially misleading appearance with cerebral metastases, risk factors and prognosis.
(BELG J MED ONCOL 2016;10(7):276–280)
Read moreBJMO - volume 10, issue 6, september 2016
F. Baekelandt MD, W. Everaerts MD, PhD, M. Albersen MD, PhD, B. Van Cleynenbreugel MD, PhD, U. Milenkovic MD, C. Assenmacher MD, S. Joniau MD, PhD
BRCA2 mutation carriers generally present with prostate cancer at a younger age, with more aggressive disease and with a higher risk of nodal involvement or distant metastases at diagnosis. We present a patient with metastatic castrate resistant prostate cancer with a BRCA2 gene mutation and its clinical significance for daily practice.
(BELG J MED ONCOL 2016;10(6):223–227)
Read moreBJMO - volume 10, issue 3, may 2016
R. Peric MD, J.G. Aerts MD, PhD
This case report describes a patient referred with apparent stage IV non-small-cell lung cancer. There was doubt about the nature of the two processes in both lungs. Interpretation of radiological images and (the decisions around) acquiring histological evidence proved to play a pivotal role in definitive staging and treatment.
(BELG J MED ONCOL 2016;10(3):101–104)
Read moreBJMO - volume 10, issue 2, april 2016
B. Dekeyser MD, M. Haagdorens MD, I. Deleu MD, E. Van Hul MD, E. Beerens MD, D. Van der Planken MD, K. Hendrickx MD, L. Verstraeten MD, Y. Geussens MD, W. Lybaert MD
A 54-year old man presented with a new-onset headache, phonophobia, tinnitus, blurred vision, and nausea. Further imaging and histological examination confirmed the diagnosis of an olfactory neuroblastoma. Olfactory neuroblastoma or esthesioneuroblastoma is a rare type of cancer, originating from the basal stem cells of the olfactory epithelium in the nasal cavity. The patient received a maximal possible surgical resection of the tumour, followed by adjuvant chemo-irradiation. Given the absence of neck metastases, no prophylactic treatment of the neck was done. Recent studies state that standard treatment of esthe-sioneuroblastoma consists of surgical resection, followed by local radiotherapy. Adjuvant chemotherapy is recommended for the locally advanced tumours. As for the treatment of the neck, current consensus is to perform salvage therapy when neck metastases are present.
(BELG J MED ONCOL 2016;10(2):69–72)
Read moreBJMO - volume 10, issue 1, february 2016
S. Maréchal MD, G. Houbiers MD, M-P. Graas MD, C. Focan MD, PhD
5-Fluorouracil is an antimetabolite frequently used in the treatment of digestive cancers. Outside well-known side effects, it may induce cardiac toxicity under various clinical forms, from chest pain to arrhythmia, or even cardiac arrest, pericarditis being one of the most uncommon.1,2 We report here the case of a 52-year-old man who developed pericarditis symptoms after continuous 5-fluorouracil infusions.
(BELG J MED ONCOL 2016;10(1):35–37)
Read moreBJMO - volume 9, issue 7, december 2015
A. De Pauw MSc, F. Boutens MD, M. Lemmerling MD, PhD, V. Renard MD
Reversible posterior leukoencephalopathy syndrome is a syndrome of heterogeneous aetiology characterised by typical clinical and radiological findings. The occurrence of reversible posterior leukoencephalopathy syndrome in cancer patients is rapidly increasing. So when a cancer patient suddenly experiences symptoms of altered consciousness, convulsions, headache and/or visual disturbances, reversible posterior leukoencephalopathy syndrome should always be included in the differential diagnosis. In this paper, we describe a case of a patient who developed reversible posterior leukoencephalopathy syndrome after receiving a regimen with carboplatin and paclitaxel.
(BELG J MED ONCOL 2015;9(7):286–89)
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