BJMO - 2021, issue 3, march 2021
Elisa Agostinetto , Daniel Eiger , Matteo Lambertini , Marcello Ceppi , Marco Bruzzone , Noam Ponde , Chris Plummer , Ahmad Hussein Awada , Martine Piccart-Gebhart , Evandro de Azambuja
Introduction: ICI can cause potentially life-threatening adverse events (AE) and their risk of cardiotoxicity has been poorly investigated. It is also unknown whether ICI combinations increases cardiotoxicity compared to single ICI. We aimed to assess the cardiotoxicity rate of ICI compared to other cancer treatments (primary objective) and of dual-agent ICI (immunotherapy combinations) compared to single-agent ICI (secondary objective).
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Hannah Van Belle , Hans Wildiers
Background: Docetaxel, carboplatin and trastuzumab, with or without pertuzumab (TCH(P)), is increasingly used for (neo) adjuvant treatment of HER2-positive early breast cancer. However, its associated febrile neutropenia (FN) risk is unclear: pivotal studies reported FN risks <10%, but in clinical practice a high FN rate (>20%) was observed. This systematic review and meta-analysis determine the FN risk associated with TCH(P) and the effect of primary prophylactic granulocyte colony-stimulating factor (PP G-CSF).
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Sofie Demasure , Isabel Spriet , Philip R. Debruyne , Annouschka Laenen , Wim Wynendaele , Marcella Baldewijns , Herlinde Dumez , Paul M. Clement , Hans Wildiers , Patrick Schöffski , Eduard Rousse , Lisa Kinget , Maarten Albersen , Benoit Beuselinck
Introduction: Only a limited number of recent phase III studies with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs), mTOR-inhibitors or immune checkpoint inhibitors (ICI) in metastatic clear-cell renal cell carcinoma (m-ccRCC) could show an overall survival (OS) benefit compared to standard of care. We aimed to study the evolution of OS of m-ccRCC patients during the last 20-years period (2000–2020).
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Rafael Caparica , Elisa Agostinetto , Lucas Vian , Marco Bruzzone , Marcello Ceppi , Noam Ponde , Matteo Lambertini , Evandro de Azambuja
Introduction/aim: The combination of CDK4-6i and endocrine therapy (ET) is standard-of- care for pts with HR+/HER2- advanced breast cancer. However, studies evaluating adjuvant CDK4-6i provided contradictory results thus far. We conducted a systematic review and meta-analysis to assess if the addition of CDK4-6i to adjuvant ET impacts on survival’s outcomes and safety of pts with HR+/HER2- EBC.
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Michael Saerens , Ingeborg Hilderson , Anne Hoorens , Celine Jacobs
Introduction: Pyrexia is a frequent complication of treatment with BRAF and MEK inhibitors. Management includes a full infectious workup, initiation of paracetamol, NSAIDs, dose interruption and steroids. In rare cases pyrexia is refractory to classic management. Pathogenesis of pyrexia shows similarities with familial mediteranian fever, a disease that usually responds well to colchicine.
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Dan Truc Nguyen , Stéphane Holbrecht , Soizic Garaud
Introduction: Immune checkpoint inhibitors (ICI) are becoming a cornerstone of therapies for many cancers. However, a new class of side effects has emerged, namely immune-related adverse events (irAEs). Many studies have suggested a potential relationship between irAEs and benefit of ICI, but little is known about the mechanisms underlying toxicity and antitumor efficacy.
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Anouk Goudsmit , Edouard Cubilier , Anne-Pascale Meert , Philippe Aftimos , Konstantinos Stathopoulos , Chloé Spilleboudt , Angela Loizidou
Background: Immunocompromised cancer patients are presumed to be at high risk of developing COVID-19 infection. Predisposing factors to contracting COVID-19 and to severe outcomes have been described in registries but were not compared between solid tumors and hematological malignancies.
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