BJMO - volume 19, issue 2, march 2025
E. Donck MD, P. de Visschere MD, PhD, C. Van Praet MD, PhD, S. Verbeke MD, PhD, S. Hendrickx MD, C. Berquin MD, S. Rottey MD, PhD, W. Verla MD, PhD, N. Lumen MD, PhD
Background: Magnetic Resonance Imaging (MRI) is advised for the diagnosis of prostate cancer (PC), and PSMA PET/CT is used for distant staging of PC. Local staging of the primary tumour with PSMA PET/CT is currently not recommended, although the primary lesion can be visualised as well. Recently, two new tumour-assessing scores were developed to optimise the diagnostic accuracy of PSMA PET/CT for the primary tumour: the PSMA-expression score and the PRIMARY score.
Objective: To evaluate the performance of PSMA PET/CT and its PRIMARY and PSMA-expression scores in the assessment of intraprostatic lesions in patients with PC. Patients and methods: This is a retrospective analysis of patients treated with radical prostatectomy for PC in a single tertiary centre between 2019 and 2022. All patients underwent preoperative prostate MRI and 18F- or 68Ga-PSMA-11 PET/CT. The medical images were pseudonymized and retrospectively assessed by two radiologists and a nuclear medicine specialist. The PSMA PET/CTs were scored according to the PSMA-expression score (PROMISE V2 framework) and the PRIMARY score. The MRIs were scored using the PI-RADS system. The accuracy of the three different scores for diagnosing high-grade PC (ISUP grade ≥3) was evaluated.
Results: The PSMA-expression score demonstrated the highest accuracy for detecting high-grade PC, with an AUC of 0.76, outperforming the PI-RADS scores from reader 1 (AUC of 0.59) and reader 2 (AUC of 0.68) and the PRIMARY score (AUC of 0.69). It had a sensitivity of 72%, a specificity of 70%, a positive predictive value of 85%, and a negative predictive value of 51%.
Conclusion: PSMA PET/CT has a promising diagnostic accuracy to detect intraprostatic lesions of high grade in patients with PC. Further validation of the PSMA PET scoring systems is warranted.
Patient summary: In this study, the performance of PSMA PET/CT (the PRIMARY and PSMA-expression scores) to detect malignant lesions in the prostate was evaluated. PSMA PET/CT and these scoring systems seem promising to detect PC and could be of interest in cases where MRI is ambiguous.
(BELG J MED ONCOL 2025;19(2):46–53)
Read moreBJMO - volume 18, issue 5, september 2024
T. Vermassen PhD, A. Decruyenaere MD, D. De Maeseneer MD, S. Rottey MD, PhD
The 2024 annual ASCO meeting offered remarkable presentations about the lastest trial updates in renal cell, bladder, testicular and prostate cancer. This article will give an overview of the key highlights in genitourinary cancers presented at ASCO 2024.
(Belg J Med Oncol 2024;18(5):206–10)
Read moreBJMO - volume 17, issue 8, december 2023
T. Vermassen PhD, A. Decruyenaere MD, D. De Maeseneer MD, S. Rottey MD, PhD
The 2023 annual ESMO meeting again offered striking presentations about the latest trial updates in genitourinary cancers, including prostate, renal cell and urothelial cell carcinomas. This article will give an overview of the key highlights presented during this meeting in this setting.
(Belg J Med Oncol 2023;17(8):313–8)
Read moreBJMO - volume 17, issue 5, september 2023
T. Vermassen PhD, A. Decruyenaere MD, D. De Maeseneer MD, S. Rottey MD, PhD
The 2023 annual ASCO meeting offered once more remarkable presentations about the last trial updates in renal cell, bladder, testicular and prostate cancer. This article will give an overview of the key highlights presented during this meeting in this setting.
(Belg J Med Oncol 2023;17(5):169–77)
Read moreBJMO - volume 17, issue 4, june 2023
A. Verbiest MD, PhD, M. Baldewijns MD, PhD, B. Beuselinck MD, PhD, P. Debruyne MD, PhD, C. Gennigens MD, PhD, G. Pelgrims MD, T. Roumeguère MD, PhD, E. Seront MD, PhD, N. Sundahl MD, PhD, S. Rottey MD, PhD
The management of renal cell carcinoma is evolving rapidly. Here, the BSMO expert panel discusses recent advances focusing on systemic therapies, and provides guidelines adapted to the Belgian context.
(BELG J MED ONCOL 2023;17(4):118–27)
Read moreBJMO - volume 16, issue 8, december 2022
A. Decruyenaere MD, S. Rottey MD, PhD, D. De Maeseneer MD, T. Vermassen PhD
The 2022 annual ESMO meeting again offered striking presentations about the last trial updates in genitourinary cancers, including prostate, renal cell and urothelial cell carcinomas. This article will give an overview of the key highlights presented during this meeting in this setting.
(Belg J Med Oncol 2022;16(8):372–9)
Read moreBJMO - volume 16, issue 5, september 2022
T. Vermassen PhD, A. Decruyenaere MD, S. Rottey MD, PhD, D. De Maeseneer MD
The 2022 ASCO Annual Meeting again offered a variety of advancements in the treatment of genitourinary cancers. In this summary, some of the highlights in the field of renal, bladder and prostate cancer will be discussed, with a particular focus on studies with a potential impact on clinical practice.
(Belg J Med Oncol 2022;16(5):214–22)
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