BJMO - volume 18, issue 7, november 2024
C. Artigas MD, PhD, A.M. Bergman MD, PhD, M. Gizzi MD, I.J. de Jong MD, PhD, D.E. Oprea-Lager MD, PhD, W.J.G. Oyen MD, PhD, M. Strijbos MD, PhD
The life expectancy and quality of life of patients with metastatic castration-resistant prostate cancer (mCRPC) continue to improve with the registration of new therapies. However, for individual patients, the appropriateness and optimal sequence of taxanes, radium-223, androgen receptor pathway inhibitors and lutetium-177-prostate-specific membrane antigen (PSMA) remains to be determined. To assess the current positioning of radium-223 and lutetium-177-PSMA as treatments for mCRPC, a consensus meeting with a multidisciplinary panel of experts from the Netherlands and Belgium was held. This article summarises the panel’s guidance on preferred sequences and the discussions of that meeting.
(BELG J MED ONCOL 2024;18(7):258–267)
Read moreBJMO - 2021, issue SPECIAL, march 2021
M. Gizzi MD
In recent years, we have witnessed a number of exciting therapeutic innovations for patients with metastatic urothelial cancer (mUC). During a lecture at the 2021 annual BMUC meeting Dr. Marco Gizzi provided an overview of these advances.
Read moreBJMO - volume 13, issue 6, october 2019
P. Ost MD, PhD, D. Schrijvers MD, PhD, L. Duck MD, M. Gizzi MD, K. Goffin MD, PhD, S. Joniau MD, PhD, S. Rottey MD, PhD, T. Roumeguère MD, PhD, E. Seront MD, PhD, N. Withofs MD, PhD, B. Tombal MD, PhD
The treatment landscape for metastatic castration-resistant prostate cancer (mCRPC) has changed dramatically with the approval of a variety of therapeutic agents including abiraterone acetate, cabazitaxel, docetaxel, enzalutamide and radium-223 dichloride and the introduction of docetaxel and abiraterone acetate in combination with androgen deprivation therapy in newly diagnosed metastatic prostate cancer. Evidence on the optimal sequence of these therapies is scarce. In practice, the most appropriate treatment (sequence) depends on patient and disease characteristics. This article summarises the recommendations of a multidisciplinary group of Belgian experts in sequencing treatments for patients with mCRPC, with a focus on radium-223 dichloride.
(BELG J MED ONCOL 2019;13(6): 240–250)
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