M-D. Tkint de Roodenbeke Archives

Molecular test algorithms for breast tumours

BJMO - volume 13, issue 2, march 2019

Ir A. Hébrant PhD, K. Punie MD, F.P. Duhoux MD, PhD, C. Colpaert MD, PhD, G. Floris MD, PhD, K. Lambein MD, PhD, P. Neven MD, PhD, M. Berlière MD, PhD, R. Salgado MD, PhD, M. Chintinne MD, PhD, K. Dahan MD, PhD, S. Dedeurwaerdere MD, J. De Grève MD, PhD, A. de Leener MD, PhD, H. Denys MD, PhD, R. de Putter MD, L. Desmyter PhD, M. Baldewijns MD, PhD, D. Feret MD, C. Fontaine MD, C. Galant MD, P. Hilbert PhD, J. Janssens MD, PhD, D. Larsimont MD, PhD, P. Lefesvre MD, PhD, T. Sticca PhD, M-D. Tkint de Roodenbeke MD, G. Van Den Eynden MD, PhD, I. Vanden Bempt MD, PhD, C. Van den Broecke MD, I. Vandernoot MD, C. Sotiriou MD, PhD, J. van Dorpe MD, PhD, H.A. Poirel MD, PhD, E. Van Valckenborgh PhD, G. Raicevic PhD, M. Van den Bulcke PhD, P. Aftimos MD

SUMMARY

In order to advise the Federal Government on all matters related to personalised medicine in oncology, including the reimbursement of molecular tests, the Commission of Personalized Medicine (ComPerMed) has applied, for the breast tumours, the same methodology as previously applied for the digestive tumours. Meaning, the different molecular tests, represented in the shape of algorithms, are annotated with test levels — which aim to reflect their relevance based on current available data and to define the reimbursement — and are documented with recent literature, guidelines and a brief technical description.

(BELG J MED ONCOL 2019;13(2):40–45)

Treatment options in patients with early breast cancer and BRCA-mutations or family history of cancer

BJMO - volume 12, issue 5, september 2018

M-D. Tkint de Roodenbeke MD, L. Buisserer , M. Piccart-Gebhart MD, PhD

Women diagnosed with BRCA1/2 mutation positive breast cancer have an increased lifetime risk of contralateral breast cancer and ovarian cancer. They benefit from risk-reducing surgical strategies such as mastectomy and salpingo-oophorectomy. For patients with BRCA mutations and hormone-receptor positive breast cancer, the option of combined bilateral annexectomy and hormonal therapy with Aromatase Inhibitor can be discussed with high-risk patients. For triple negative breast cancer with BRCA mutation, there is some evidence that adding platinum-agents in the neoadjuvant setting improves the pathologic complete response. Lastly, ongoing clinical trials testing the efficacy of poly (ADP-ribose) polymerase inhibitor therapy in patients with BRCA1/2 mutations will be determinant for the future guideline recommendations in determining best treatment options for these patients.

(BELG J MED ONCOL 2018;12(5):239–246)