BJMO - volume 18, issue 7, november 2024
L. Decoster MD, PhD, K. Vekens MD
The introduction of targeted therapies has dramatically changed the outcome for patients with oncogenedriven non-small cell lung cancer. Recent advances have led to the introduction of targeted therapies in early-stage non-small cell lung cancer, as well as the development of new strategies to overcome resistance. The current manuscript gives an update on targeted therapies in oncogene-driven non-small cell lung cancer.
(BELG J MED ONCOL 2024;18(7):253–257)
Read moreBJMO - volume 11, issue 8, december 2017
L. Decoster MD, PhD, K. Vekens MD, S. Mignon MD, D. Schallier MD, PhD, J. De Grève MD, PhD
Antibodies against programmed cell death-1 (PD-1) and its ligand (PD-L1) have become standard-of-care in the second-line treatment for advanced non-small cell lung cancer after failure of first-line chemotherapy. The observed durable responses as well as the favourable toxicity profile have moved these agents to first-line studies for advanced non-small cell lung cancer. In tumours with high PD-L1 expression, pembrolizumab is registered as the preferred first-line treatment. Further studies are currently focusing on combination strategies. The major future challenge will be selecting the optimal treatment strategy for the patient.
(BELG J MED ONCOL 2017;11(8):380–385)
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