BJMO - volume 19, issue 1, january 2025
L. Naert MD, S. Proost MD, A. Driessen MD, PhD, T. Vandamme MD, PhD
Jaundice in a patient with renal cell carcinoma is most frequently caused by liver metastasis and has a poor prognosis. However, multiple paraneoplastic phenomena are described in renal cell carcinoma, including a Stauffer syndrome variant with jaundice. In this case report we present the case of a woman in her 80s with jaundice in a newly diagnosed renal cell carcinoma. Hepatic metastasis was ruled out, and the differential diagnosis with the Stauffer syndrome, variant, vanishing bile duct syndrome, and hepatotoxicity was made. Due to the rapid fatal ending, it was not possible to evaluate the reversibility of the hepatic dysfunction after nephrectomy.
(BELG J MED ONCOL 2025;19(1): 36–39)
Read moreBJMO - volume 12, issue 3, february 2018
T. Vandamme MD, PhD, Isabelle Maurissen , W. Lybaert MD, Marc Simoens , P. Abrams , A. Driessen MD, PhD, B. Op de Beeck , Wim Demey MD, T. Rondou , M. Ulenaers MD, G. Vanhoutte , Marc Peeters , Steering Committee , NET-specialists
BJMO - 2017, issue 3, february 2017
W. Lybaert MD, T. Vandamme MD, PhD, M. Simoens , I. Dero MD, Wim Demey MD, T. Rondou , A. Cuypers , P. Abrams , C. Mattelaer , A. Driessen MD, PhD, B. Op de Beeck , O. D’Archambeau , G. Roeyen MD, PhD, L. De Backer , M. Peeters MD, PhD, NET specialists NETwerk Steering Committee
BJMO - volume 9, issue 5, september 2015
A. Jouret-Mourin MD, PhD, C. Cuvelier MD, PhD, P. Demetter MD, PhD, N. D’Haene MD, PhD, A. Driessen MD, PhD, A. Hoorens MD, PhD, N. Nagy MD, X. Sagaert MD, PhD, P. Pauwels MD, PhD, On behalf of the Working Group of Digestive Pathology and the Belgian Society of Pathology.
There is an urgent need for predictive biomarkers in several cancers. In colorectal cancers, KRAS exon 2 mutation analyses were mandatory when considering anti-epidermal growth factor antibody therapy with agents such as cetuximab or panitumumab. However, since the introduction of this testing, a cohort of patients still did not appear to benefit from this therapy. Recently, additional testing for KRAS exon 3 and 4, and NRAS considerably improved the predictive power for therapy success. Therefore, an update of the Belgian guidelines for RAS testing was urgently needed.
(BELG J MED ONCOL 2015;9(5):183–90)
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