Journal issues > Issue 1, January 2025 > Jaundice in a patient with renal cell carcinoma: Stauffer syndrome or not?

Jaundice in a patient with renal cell carcinoma: Stauffer syndrome or not?

By: L. Naert MD, S. Proost MD, A. Driessen MD, PhD, T. Vandamme MD, PhD

SUMMARY

Jaundice in a patient with renal cell carcinoma is most frequently caused by liver metastasis and has a poor prognosis. However, multiple paraneoplastic phenomena are described in renal cell carcinoma, including a Stauffer syndrome variant with jaundice. In this case report we present the case of a woman in her 80s with jaundice in a newly diagnosed renal cell carcinoma. Hepatic metastasis was ruled out, and the differential diagnosis with the Stauffer syndrome, variant, vanishing bile duct syndrome, and hepatotoxicity was made. Due to the rapid fatal ending, it was not possible to evaluate the reversibility of the hepatic dysfunction after nephrectomy.

(BELG J MED ONCOL 2025;19(1): 36–39)

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