Highlights in head and neck cancer

SUMMARY

The ESMO Congress was held from 20 until 24^th October 2023 in a live and virtual format. During this Congress, the selective RET inhibitor selpercatinib in comparison with cabozantinib or vandetanib settled a new standard-of-care in the first-line treatment of unresectable locally advanced or metastatic RET-mutant medullary thyroid cancer. A meta-analysis of the use of anti-EGFR monoclonal antibodies refined the place of cetuximab in locally advanced (LA) head and neck squamous cell carcinoma (HNSCC). Pembrolizumab seems more efficacious and less immunosuppressive in an adjuvant compared to concomitant setting in LA HNSCC. Detection of circulating tumour DNA (ctDNA) seems feasible before and after curative-intent treatment for LA HNSCC and is strongly correlated with progression-free survival (PFS) and overall survival (OS). In this report, the most important headlines will be discussed, with comments on the clinical relevance of the different studies.

(Belg J Med Oncol 2023;17(8):286–91)